WebJan 25, 2024 · Maribavir targets the viral UL97 kinase and showed promising results [21,22]. A phase II clinical trial of maribavir showed ~65% response across all doses. There were no major safety issues and no bone marrow suppression, but CMV recurrences occurred in 35% of the participants . In a phase III clinical trial, maribavir was superior … WebIn a phase 3 open-label clinical trial, 352 transplant recipients with CMV who did not respond to treatment were randomly assigned to receive maribavir or another antiviral treatment that could include 1 or 2 of the following CMV medications: ganciclovir, valganciclovir, foscarnet, or cidofovir. Efficacy was defined as having a plasma CMV DNA ...
NDA 215596 - Food and Drug Administration
WebApr 10, 2024 · Following oral administration, maribavir is rapidly absorbed, with mean peak plasma concentrations (C max) around 1–3 hours after dosing, and eliminated with a half-life of ≈5–7 hours. 12 Maribavir has time-independent pharmacokinetics (PK), and its accumulation ratio is close to 1 following twice-daily dosing. 13 Studies in Western ... WebNov 17, 2024 · Maribavir has also been evaluated for use in patients with CMV DNAemia but no CMV disease. A phase II, randomized, dose-ranging, open-label trial included 82 HCT and 77 SOT recipients who presented with asymptomatic CMV viremia (1000–100 000 copies/mL in blood or plasma) without genotypically proven drug resistance [ 30 ]. rupi eyebrow lyndhurst
Maribavir for Treatment of Resistant or Refractory CMV …
WebMaribavir is a benzimidazole riboside with activity against cytomegalovirus (CMV). The safety and efficacy of maribavir for preemptive treatment of CMV infection in transplant recipients is not known. http://mdedge.ma1.medscape.com/hematology-oncology/article/236719/transplant/maribavir-seen-superior-other-antivirals-cmv-clearance WebMaribavir is a potent and specific inhibitor of the CMV UL97 kinase (Biron et al., 2002) that has been investigated in vitro and in clinical trials over an extended period. The UL97 kinase has important biological functions during CMV replication, including cell cycle modulation and nuclear egress of nascent viral particles ( Marschall et al ... rupi eyebrow place fair lawn nj